The billionaire Virgin founder, who lives in the British Virgin Islands, has made repeated claims about his dislike for Brexit.
The 67-year-old businessman described Brexit as the “saddest thing” that could happen to the UK in his latest tirade against the historic referendum.
Speaking to Irish broadcaster RTE, Branson said: “The older generation is dying off.
So whether there’s a second referendum before Brexit happens – I’m sure the Tory party will do their best not to allow that to happen – but I think within five years there will be a government in power in Britain that will ask Europe for a chance to let Britain re-enter.
“Because there will be so many young people who will be a little bit older by then and so many of the older grandparents who voted for Brexit will have died off, I think that Britain will become part of Europe again.”
The billionaire also took aim at Boris Johnson and the “older group of British people” who “took a gun and shot at their feet” for listening to the Foreign Secretary and other Leave campaigners.
He added: “There was a ghastly, ghastly misrepresentation of reality, a picture was pained that was completely unreal.”